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M94A2763.TXT
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1994-10-25
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Document 2763
DOCN M94A2763
TI Antigens and antibodies for HIV type 1 in serum, saliva and gingival
fluid in patients with advanced disease.
DT 9412
AU Ramos J; Arce AY; Santos SI; Morones MT; Mendoza J; School of Medicine,
U.A.N.L., Monterrey, Nuevo Leon, Mexico.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):230 (abstract no. PB0348). Unique
Identifier : AIDSLINE ICA10/94369812
AB OBJECTIVES: To determine the presence of antigens (Ags) and antibodies
(Abs) for type 1 HIV in serum, saliva and gingival fluid in patients in
stage 6 Walter Reed (WR) classification; and to describe the spectra of
oral lesions. METHODS: 25 male patients who met the criteria of the WR6,
attending the infectious disease Clinic, accepting to participate,
underwent extensive evaluation and X rays. Saliva was obtained with a
Pasteur pipette, gingival fluid was collected with filter and
nitrocellulose paper. Blood was drawn in the same visit. Ags were
determined by ELISA (Organon) and Abs by ELISA (Behring) a qualitative
result was obtained in both tests. TABULAR DATA, SEE ABSTRACT VOLUME.
DISCUSSION AND CONCLUSIONS: The presence of HIV Ags in the gingival
fluid was found in 12% of these patients with advanced disease and 12%
additional in saliva for a total of 24% in oral fluids. The Abs in
saliva were present only in half of the patients, cautioning reliability
of saliva as a diagnostic tool. Extensive periodontal damage is present
in most of the individuals at this stage of HIV infection. Interestingly
hyperpigmentosis was present in the majority of our patients contrary to
reports in the literature which regarded it as a rare condition.
DE Adult Comparative Study Enzyme-Linked Immunosorbent Assay Exudates
and Transudates/*IMMUNOLOGY False Negative Reactions
Gingiva/*IMMUNOLOGY Human HIV Antibodies/*ANALYSIS/BLOOD HIV
Antigens/*ANALYSIS/BLOOD HIV Infections/COMPLICATIONS/*IMMUNOLOGY
HIV-1/*IMMUNOLOGY Male Periodontal Diseases/COMPLICATIONS
Pigmentation Disorders/COMPLICATIONS Saliva/*IMMUNOLOGY Salivary
Proteins/*ANALYSIS Specimen Handling MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).